What are the critical problems with DSP monitoring in the biopharmaceutical industry today?

 

In DSP, the challenges are highly critical and deal with the purity and concentration of the final product obtained through chromatography or ultra-filtration processes and steps like viral inactivation. The duration of these processes are typically one or two hours. For this reason, only in-line or on-line monitoring is relevant. The lack of current analytical monitoring induces strong issues in DSP development and justification in the biotech industry.